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I am a 45 year old female and I suffer from urinary incontinence for some 5 or 6 years now after a surgery that has somehow affected these functions of my body. I have to visit the bathroom every 20 minutes and this fact produces sad impact on my personal life, my activities and my career as well. I have consulted different specialists and they prescribed me with numerous pills and also different therapies, but nothing actually helped. I mean some methods helped, but only temporarily and afterwards all the symptoms used to come back. I actually almost lost hope to get rid of the disorder. I do not plan long journeys to places I don't know, I seldom go on holidays to other countries, I try not to travel by plane and of course I can not visit the swimming pool. At night I visit the toilet from 5 to 7 times and of course it also affects my quality of sleep. However about three months ago I came across Darifenacin flyer in the local hospital. The information was so optimistic and encouraging that I decided to try out this drug. I bought it the same evening and started taking the medication. After three days I noticed significant changes for the better. At night I had to visit the toilet 2 times only and during the day it as much easier for me to control my urge to urinate. I like the medication greatly as it produces stable results for three months already. And I would recommend Darifenacin to all other people with similar symptoms.

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I am 35 years of age and I started experiencing problems with urination about 2 years ago after giving birth to my son. I thought it was just a temporary disorder that will disappear after my health condition stabilizes but urinary incontinence remained after all the problems caused by childbirth went away. It is naturally very inconvenient and even embarrassing. I can not plan my day as before, I can't go somewhere without carefully thinking over the route. Sometimes when I have to run a bit to catch a bus or just to be on time somewhere I can lose several drops of urine and the problem then becomes to visit a toilet but not to win time. It is absolutely discouraging to discuss but I also have serious problems with personal life as I can not control urination during sexual intercourse as well. The first time I encountered this problem I was devastated, embarrassed and couldn't think about another sex with a man. You can imagine how unbearable this seemingly minor disorder makes my life. My son is 3 years now and I got divorced a year ago, not because of the health issue, it was just a matter of difference in characters. But now I am trying to get into a new relationship, start my life from a new point and these problems with my urinary bladder make all my efforts meaningless and comic. However last week I started using Darifenacin after my friend recommended the medication to me. She had similar problems and Darifenacin helped her forget about uncontrollable urination. I also noticed changes in spite of the fact that I've been on the medication for 5 days only. The number of my nocturnal toilet visits decreased from 6-7 to 4-5. It is a significant change for me. And I am all very optimistic. In the daytime I also feel better and do not have to urinate that often. Besides no I do not lose drops of urine when coughing. That's great! I know Darifenacin will help me get my life back!

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The Panel notes that if a patient has good symptom control and tolerable side effects on an IR formulation, then there is no need to change to an ER formulation.

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Zinner N, Tuttle J and Marks L: Efficacy and tolerability of darifenacin, a muscarinic M3 selective receptor antagonist (Md SSRA), compared with oxybutynin in the treatment of patients with overactive bladder.

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