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Coumadin (warfarin) () is an anticoagulant that is indicated for prevention of blood clots after strokes, heart attacks, and as a prophylaxis treatment in atrial fibrillation.
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As for the more powerful class of drugs, the Disease Modifying AGents (DMARDs) like methotrexate, these are not contraindicated in the treatment of RA in someone taking coumadin.
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In addition, Coumadin is used to prevent or treat swelling and blood clot in a vein (venous thrombosis) and blood clot in the lung (pulmonary embolism).
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The researchers from Glendale, AZ, suggest that doctors consider cranberry as a potential interaction if a patient ends up with an elevated INR and a risk for bleeding.
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The fall in platelet count almost always occurs between day 5 and day 15 after introduction of heparin but can develop earlier in patients exposed to heparin during the previous 3 months.
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Landfeld CS, Goldman L "Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy.
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Pharmacodynamic mechanisms for drug interactions with Coumadin are synergism (impaired hemostasis, reduced clotting factor synthesis), competitive antagonism (vitamin K), and alteration of the physiologic control loop for vitamin K metabolism (hereditary resistance).
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Inter- and intrapatient differences between generic warfarin and Coumadin were compared, and overall study patient results were compared with those of a Coumadin control group.
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PTT can also be indicative of low levels of certain medications--usually, blood thinners, such as heparin or warfarin (Coumadin).
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